5. Autoimmune Hemolytic Anemia

Autoimmune Hemolytic Anemia

Thymoma with Autoimmune Hemolytic Anemia

A 38-year-old Japanese male was referred to our hospital with abnormal chest X-ray results and severe Coombs-positive hemolytic anemia. He was diagnosed with a stage IV, WHO type A thymoma and was treated with oral prednisolone (1 mg/kg/day) and subsequent chemotherapy. After chemotherapy, the patient underwent surgical resection of the thymoma. Hemolysis rapidly disappeared and did not return ...

Immunotherapy-associated autoimmune hemolytic anemia

BACKGROUND Immunotherapy has been widely used in the treatment of several solid and hematologic malignancies. Checkpoint inhibitors have been the forefront of cancer immunotherapy in recent years. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) pathway are the prototypic checkpoint targets for immunotherapy. When combined, CTLA-4 and PD-1 checkpoint inhib...

Reticulocytopenia in autoimmune hemolytic anemia.

ETICULOCYTOSIS is gemserally regarded as a characteristic feature of the hensolytic symsdrome. The outpouring of young red cells is ouse of the bone marrow’s reactiomss to the challenge of aisemia, atsd the numssber of reticulocytes it produces is oftets a good measure of the severity of the hemolytic process. Whets the red cell life spams is very short mssost of the cells ims the circulation n...

nTregs in Autoimmune Hemolytic Anemia

Objectives: Naturally occurring regulatory T cells (nTregs) play an important role in immunologic tolerance and control immune-mediated pathology in murine models of autoimmune hemolytic anemia. Our aim was to measure nTregs and levels of interleukin (IL) 10 and IL-12 in peripheral blood mononuclear cell (PBMC) cultures from patients with idiopathic warm autoimmune hemolytic anemia (wAIHA) in a...